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10.13386/j.issn1002-0306.2021060137 112 XiaoK.LuoY.LiangX.TangJ.WangJ.XiaoQ.et al (2021)
These three receptor pathways form the foundation of next-generation multi-agonist therapies that deliver deeper, more sustained weight-loss and metabolic improvements than single-target drugs
and in the SUSTAIN 6 trial, a 36% reduction was reported in the occurrence of this end point [21]
Most notably, the patients enrolled in LEADER had chronic cardiovascular risk (either a pre-existing cardiovascular condition or a high risk for cardiovascular disease), while only those individuals who were within 180 days post-acute coronary event and, hence, at the highest risk of a further cardiovascular event, were included in ELIXA
Moreover, the increased risk of dehydration, electrolyte imbalance, hyperlipidemia, and kidney stone formation is of particular concern in older adults with comorbidities, including cardiovascular and renal disease
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