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The following dosage recommendations apply, unless otherwise prescribed: At the beginning of treatment, 1 vial of VITAMIN B12 DEPOT-ROTEXMEDICA (equivalent to 1000 g hydroxocobalamin acetate) is administered twice a week for the first few weeks after diagnosis

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J Chromatogr B Biomed Sci Appl 746:297304 Pan Y, Berman Y, Haberny S, Meller E, Carr KD (2006) Synthesis, protein levels, activity, and phosphorylation state of tyrosine hydroxylase in mesoaccumbens and nigrostriatal dopamine pathways of chronically food-restricted rats

These are the earliest signals of where the next cycle is heading

doi:10.1056/NEJMra021261

doi: 10.1053/j.gastro.2017.05.056