Older adults People over 65 generally tolerate GLP-1 medications well, but the transition period carries higher risk for dehydration, hypotension, and falls related to GI side effects
Nausea, vomiting, and diarrhea are among the most common adverse effects of GLP-1 receptor agonists, with frequencies varying by product and dose
Other oral medications with narrow therapeutic windows medications such as certain thyroid medications and oral antibiotics that depend on consistent gastric absorption timing may be affected
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Tirzepatide Once Weekly for the Treatment of Obesity New England Journal of Medicine 387(3) 2022PMID: 35658024 NEJM 3 Drucker DJ Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 Cell Metabolism 27(4) 2018PMID: 29617641 PubMed 4 Rubino D, Abrahamsson N, Davies M, et al