It is naturally present in human blood, saliva, and urine
the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use
Dose Rate: Lambs: 0.5 mL at marking or weaning Sheep: 1.0 1.5 mL pre-lambing Calves: 2 3 mL from 2 months of age Cows: 4 6 mL pre-calving The frequency of dosing should be related to the severity of the deficiencies
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Both endotoxin replicates passed at an assay sensitivity of 0.05 EU/mL or lower, and the PCR screen returned no detectable microbial DNA