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This is not a subtle effect
For B12: monthly for wellness, or weekly for 48 weeks to correct confirmed deficiency
After initial results, many researchers maintain lower frequency protocols rather than stopping entirely
collection, management, analysis, and interpretation of the data
Moreover, GHK was also reported to decrease the gene expression of IGF-1 (Pickart et al., 2014), which stimulates TGF-1 transcription and protein expression in dermal fibroblasts in vitro (Ghahary et al., 1998)
Because a large number of comparisons were performed on the relative abundance data, main effect results from these analyses also underwent a BenjaminiHochberg false discovery rate (FDR) correction for multiple comparisons, and instances where a result was significant after this correction have been duly noted
