It has demonstrated significant effects on collagen synthesis and angiogenesis
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Compound 38 , containing a (methoxyethyl)pyrazole group, emerged as a successful substitution, enhancing selectivity (pIC 50 for other PDEs 95-fold over other PDEs), and excellent metabolic stability (RLM t 1/2 : 105 min)
[3] Epitalon reduced the number of spontaneous tumors and the number of metastases in mice that did develop spontaneous tumors in an experiment on one-year-old female mice of the C3H/He inbred strain, and is speculated to have oncostatic and anti-metastatic properties
A systematic review and meta-analysis of 10 randomized controlled trials found that citicoline therapy in acute ischemic stroke (provided intravenously and/or orally between 8 hours and 14 days post stroke) was linked to a slightly higher rate of independence (101)