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However, by the time symptoms appear, the disease has already affected different organs and the consequences can be irreparable: Early Dissemination Phase (The bacteria spread) If the bacteria are not stopped, they enter the bloodstream and lymphatic system, spreading throughout the body

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These effects were generally mild to moderate in intensity and were most frequent during the dose escalation period, becoming less common as participants remained on their maintenance dose

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Intensive studies are still required to unravel the crosstalk between different NRF2-regulated metabolic pathways and diseases and enable the development of a better strategy for combating human diseases

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Deletion of the Sap structural ATPase protein, SapF, simultaneously inhibits recovery of depleted internal haem-iron stores and reduces the ability of NTHi to colonise the nasopharynx or cause acute infection in a chinchilla model of acute OM (Vogel et al., 2012)

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