![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://www.researchgate.net/publication/363201315/figure/fig3/AS:11431281082605778@1662084799021/Efficacy-of-tirzepatide-in-phase-2-GPGB-14-and-phase-3-SURPASS-1-to-5-15-19.png)
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Akkermansia muciniphila , Clostridium butyricum , Roseburia , and Faecalibacterium all strong SCFA producers
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs13300-024-01660-0/MediaObjects/13300_2024_1660_Fig3_HTML.png)
Theyre different from glipizide ER tablets, which are an extended-release (ER) form of the drug
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://ars.els-cdn.com/content/image/1-s2.0-S1751991825000816-gr1.jpg)
VadiniFSimeonePGBoccatondaAGuagnanoMTLianiRTripaldiRet al
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://diabetesonthenet.com/wp-content/uploads/9_Distilled_Tirzepatide_Table1.png)
In addition, SOD was measured using specific colorimetric assay kits (Arbor Assays Company, 1514 Eisenhower Place Ann Arbor, Michigan 48108 USA, Catalog Number K028-H1), while GPx was measured using particular colorimetric assay kits (BioAssay Systems Company, Hayward, CA 94545, USA, Catalog Number: EGPX-100) following the manufacturers instructions for each test
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://www.researchgate.net/publication/386320227/figure/fig2/AS:11431281294170225@1733081439535/Alternative-dosing-regimens-of-tirzepatide-decrease-costs-and-maintain-efficacy-Panel-A.png)
In other words, GLP-1s can help people create the energy deficit that is necessary to lose weight
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://www.nejm.org/cms/asset/52963c11-ac41-4462-9e24-4c95e167fad6/nejmoa2404881_f1.jpg)
14,15 Residual risk for another cardiovascular event in people with obesity and known heart disease remains despite treatment of known cardiovascular risk factors such as high blood pressure and high cholesterol according to standard of care treatments
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Post Hoc Analysis of SURPASS-1](https://miro.medium.com/0*8Lu0qUs1kt9cPCOs.png)
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