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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist designed to bind to GLP-1 receptors, which help regulate appetite.[4] Semaglutide was originally developed as a treatment for T2D to improve blood sugar levels, but clinical trials later showed that patients also lost weight while taking it.[4-8] Additional studies support semaglutides effectiveness in promoting weight loss in non-diabetics.[5,8,11] Semaglutide supports weight loss by suppressing appetite, delaying stomach emptying, and stimulating insulin secretion.[4] It is typically used alongside dietary changes and exercise in adults with and without diabetes.[4] All GLP-1 medications require a prescription from a healthcare provider

N Engl J Med 393:2636 Wharton S, Freitas P, Hjelmesth J et al (2025) 1966-LB: efficacy and safety of semaglutide 7.2 mg in ObesitySTEP UP trial

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