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The expression of genes involved in gluconeogenesis, glycogenolysis, lipid synthesis and transport, and catabolism were altered in untreated Hz animals and the expression of most of them was normalized by IGF-1 therapy

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Although early pregnancy registries have not identified a stable teratogenic pattern, current guidelines recommend strict precautionary washout periods (4448), current guidelines typically adopt a defensive posture, recommending strict washout periods prior to planned conception (17, 43)

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