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The pivotal cardiovascular trial for oral semaglutide is the SOUL trial published in the New England Journal of Medicine in 2025
Thankfully, pill-format varieties are also available, which may help patients who struggle with negative addiction-related associations to injections
The numbers As of July 31, 2025, the FDA had received a combined 1,150 adverse event reports related to compounded versions of semaglutide and tirzepatide
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