Overall fat mass percentage is also reduced by supplementation and lean body mass is increased
Specifically, Phase 3 trials are also exploring its efficacy in treating osteoarthritis and metabolic dysfunction-associated steatohepatitis (MASH), formerly known as fatty liver disease
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The weight loss outcomes reported in those trials reflect combined treatment, not medication alone
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When treatment is titrated toward weight loss rather than glycemic control, average reductions can be much larger, with a trial-level result of 14.9% body weight loss over 68 weeks under a weight-focused escalation protocol