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Although substantial weight loss can reduce pathological joint loading and systemic inflammation, the direct pharmacological effects on synovial fibroblastsattenuating their inflammatory signalling and fibrotic activation may offer an additional, disease-modifying and analgesic mechanism that targets the local synovial environment, driving pain and structural progression
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Hernandez AF, Green JB, Janmohamed S, DAgostino RB Sr., Granger CB, Jones NP, et al
33.5 min 4095% B
