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The mechanisms underlying AHR can be broadly categorized as follows: (1) hypertrophy of airway smooth muscle cells and increased contractility [46], (2) loss of the maximal plateau of contraction observed in normal bronchi upon inhalation of bronchoconstrictive agents due to airway inflammation [47], (3) thickening of the airway wall due to edema and structural remodeling, leading to airway smooth muscle contraction [48], and (4) sensitization of sensory nerves by inflammatory processes [49]

Abstract The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals

Alternative approaches to consider Before committing to an untested combination, researchers should consider whether simpler approaches might achieve similar goals with known safety profiles

NF-kB suppression reduces joint inflammation

The Challenge Detecting neutralizing antibodies posed several unique challenges

Few generic companies have that