Korphaisarn K, Morris V, Davis JS, Overman MJ, Fogelman DR, Kee BK, Dasari A, Raghav KPS, Shureiqi I, Trupti M, Wolff RA, Eng C, Menter DG, Hamilton S, Kopetz S
Therefore, glucose concentrations found within the majority of the brain in vivo under physiological and pathophysiological conditions are within the 0.2 to 5 mM range [73-76], and it seems that the GE and GI neurons are mainly responsible for glucose sensing, since it is unclear whether brain glucose levels ever exceed 5 mM in the presence of an intact blood brain barrier
PMID: 18644225
Pfizer had failed in its previous attempts to create a viable GLP-1 contender
Maintenance dosing 4 mg data
Staying within the broader abdominal zone but well clear of the navel gives you a large, consistent target area with good medication uptake