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Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment
Animal Model:NMRI-Hannover (male, 30 g, deep partial skin thickness burns induced by 5 s direct flame exposure covering 20% total body area) [2] Dosage:i.p.: 10 ng/kg, 10 g/kg
Water retention: Slight puffiness in the hands or feet, most common during the escalation phase and typically self-limiting
Ncgc00255351-01 163
Proposed Mechanism Pathway: BPC-157 NO System Modulation Vascular Homeostasis / VEGF/VEGFR2 Upregulation Akt-eNOS Activation Angiogenesis / FAK-Paxillin Activation Cell Migration (40% increase) / EGR-1 Upregulation Growth Factor Sensitivity Tissue Regeneration Comparative Profile: RESEARCH APPLICATIONS Wound Healing Models: Extensively studied across all three healing phases
Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, Kandel ER
