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If these findings are borne out in larger studies over extended follow-up periods, it could possibly be the most dramatic change in treating Type 1 diabetes since the discovery of insulin in 1921. During the study period, the participants mean HbA1c reduced to 5.9 at six months and 5.7 at 12 months

Pigmentations do fade with regular use but this is reversible

The FDAs January 2026 review covered over 100,000 patients across 91 trials and resulted in a request to remove suicidal ideation warnings from Wegovys label

& Noelle, R

Table 1 gives a summary of the clinical phase III studies with at least 52 weeks duration on the efficacy of DPP-4 inhibitors compared to sulfonylureas as add on therapy to metformin, respectively, in patients not reaching their glycaemic goals with a monotherapy of metformin

Lets break down how each works