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1 Vertex Pharmaceuticals Incorporated, Boston, MA, USA, 2 T1D Exchange, Boston, MA, USA, 3 University of California, San Diego, Encinitas, CA, USA

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This effect can occasionally cause gastrointestinal adverse effectsnausea, vomiting, and abdominal discomfortparticularly during dose escalation

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Rotate injection sites weekly (abdomen, thighs, upper arms) to minimize local skin irritation

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