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Oxidative Stress and Critical Illness Oxidative stress is thought to play an important role in the pathogenesis of many diseases in humans, to include cardiovascular disease, chronic inflammatory disorders, and various cancers

CONCLUSIONS Aging is the major risk factor for CVD due to the development of vascular dysfunction, particularly arterial stiffening and endothelial dysfunction

The Conservative Position Wait for better evidence

Another thing to consider is wich brand of hydroxycobalamin you use

Its a derivative of angiotensin IV, a peptide in the reninangiotensin system, but was chemically modified to make it far more potent and stable

Patients should be educated about the importance of maintaining treatment adherence, as discontinuation leads to recurrent deficiency within months to years