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It has demonstrated a strong safety profile and is currently used for non-therapeutic experimental applications only

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For this reason, Gao and his group developed a series of nanoplatforms on the basis of acidic cleavable ligand modification

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Management: Gradual fiber increase, water, light activity

Vascular damage is evident as a loss of tight junction proteins on endothelial cells, an increase of permeability and the detachment of astrocytes and pericytes (Figure 1) Dysregulation contributes to cerebrovascular accidents, generates inflammation, and is linked to neurodegenerative diseases, epilepsies, and neuroinflammatory disorders, including multiple sclerosis (Engelhardt and Ransohoff, 2011