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More comprehensive insight into the effects of GLP-1 RAs on gastrointestinal and central nervous system functions is required

Guanosine and uroguanosine, which target guanosine cyclase (GC-C) receptors in the intestine and kidney, lead to elevated intracellular cGMP concentrations, and high GC-C expression in L cells is associated with regulation of GLP-1 release (Friedlander et al., 2011)

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Patients should be aware that research in this area is ongoing, and long-term safety and efficacy data may be limited for certain therapies

Nevertheless, certain common themes emerge (Fig