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Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit, selected frailty biomarkers (interleukin-6, tumor necrosis factor-alpha, and insulin-like growth factor-1), physical function, cognitive function, nutritional status and biochemical profile
The physiology is wellestablished, but todays demand reflects an increasingly obesogenic landscape that continues to drive chronic positive energy balance
While GLP-1 receptor agonists can help promote fat loss and improve metabolic health, they can also lead to unintended muscle loss if not paired with strength training
Eric Jermyn, a licensed insurance broker and consultant with Bangor-based Cross Insurance, estimates that fewer than 10% of the thousands of employers he works with cover GLP-1s for weight loss, though many more cover it for certain conditions like diabetes
& Feig, V
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