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Clinical isolates show considerable genomic diversity, including chromosomal duplications and non-classical mutations, complicating treatment strategies (Priest et al., 2022
The dosing ramps up across the first cycle: Days 1 through 15: 4 units (1 mg/day) Days 16 through 30: 8 units (2 mg/day) After 30 days, patients take 30 days off before starting the next cycle
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