In the 5xFAD mouse model (a transgenic AD model overexpressing five familial AD mutations), adding low-dose fiber to a high-sugar diet reshaped gut microbiota and improved AD-like pathology, identifying a reproducible set of fiber-sensitive bacterial taxa
Nutrients are normally absorbed early in the small intestine, but an increase in viscosity and subsequent slowing of nutrient degradation and absorption leads to increased delivery of nutrients to more distal regions of the small intestine (e.g., distal ileum), where they are not normally present
This is especially challenging for companies that operate across multiple markets as there can be a high level of variation in the type of claims permitted for different food and beverage product types. But the knock-on impact of these varied regulations could even mean less innovative beverages being launched into this category
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So weve used 72 weeks as our benchmark for stopping treatment