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A 2025 systematic review and meta-analysis in JAMA Psychiatry found no overall increase in psychiatric side effects, including depression, with GLP-1 medications
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In the 24-week, placebo-controlled factorial study of initial therapy with JANUVIA in combination with metformin, the incidence of hypoglycemia was 0.6% in patients given placebo, 0.6% in patients given JANUVIA alone, 0.8% in patients given metformin alone, and 1.6% in patients given JANUVIA in combination with metformin
doi: 10.1056/nejmoa1411481
In a similar randomized clinical trial with a smaller sample size, Abdelfattah et al., confirmed that adding L-carnitine to clomiphene citrate in the follicular phase and continuing administration into the luteal phase in clomiphene-resistant patients can improve ovulation quality and the rates of chemical and clinical pregnancy [18]
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