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However, it must be stressed that, despite the lack of reproductive improvement, even low doses of GLP1/E were sufficient to markedly improve the metabolic perturbations in PWA mice, thus defining an optimal scenario for occasions in which the main therapeutic objective would be metabolic normalization rather than reproductive rescue, as is actually the case for most women with PCOS, without pregnancy desire, which are submitted to continued hormonal contraception plus metformin treatment

(Surgery for Obesity and Related Diseases, 2023) reported mean weight loss of approximately 10-12% with semaglutide in post-bariatric patients over 612 months, though results varied considerably between individuals

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Repeated esophageal dilations may be necessary as a stricture develops, with one review showing 35% requiring more than seven dilations