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Either a vascular obstruction (ischemic stroke in over 80% of cases) or a vascular rupture with bleeding within the brain (hemorrhagic stroke) are the offending mechanisms

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Bone loss during the fat loss period (fat loss model in obese rats) Experimental Design: Animals: Obese SD rats induced by high-fat diet were randomly divided into an obesity control group, a simple weight loss group (30% calorie restriction), and a weight loss+AOD 9604 group (500 g/kg/day)