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Reagent 4
L-carnitine can be converted by gut microbiota into trimethylamine, which the liver converts into TMAO
Thus, studies in mice have revealed a multistep metaorganismal pathway that is initiated by sequential gut microbiotadependent conversions of oral l-carnitine into an atherogenic intermediate, BB, which is then converted into TMA, the immediate precursor for host hepatic transformation into TMAO (i.e., l-carnitine BBTMATMAO)
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This is due to a decrease in its own synthesis
Cheung, C
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