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Risks and Safety Considerations to Discuss With Your Doctor Key risks include cardiovascular effects from both agents, hormonal fluctuations due to rapid weight loss altering SHBG and free testosterone, gastrointestinal side effects, and the unknown combined safety profile of an unlicensed drug alongside a controlled hormone therapy

"Just to make sure I didn't notice anything weird." Katie says it's also made her hair thicker and improved her skin texture

The GLP-1 RA and GIP receptors are effective in regulating appetite and blood sugar levels

doi: 10.1369/jhc.2008.952101 43 PykeCHellerRSKirkRKOrskovCReedtz-RungeSKaastrupPet al

A study published in The New England Journal of Medicine by Wilding et al

Some people report less interest in alcohol on tirzepatide, and early studies are encouraging