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The appetite suppression they produce is significant

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GLP-1 boosts insulin, too, but it also suppresses glucagon (a hormone that helps maintain blood sugar levels), slows digestion, and helps reduce appetite

These options pair well with semaglutide by reinforcing feelings of fullness and reducing between-meal snacking

"If it is not broken, do not fix it" applies here

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes