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Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)

Fluid retention, dose titration phases, metabolic adaptation, dietary habits, and underlying health conditions can all contribute to unexpected weight changes during treatment

Dose Dependency and Re-challenge: Be aware that symptoms may be dose-dependent