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From a translational standpoint, catestatin may be more tractable as a pathway biomarker or as a guide for targeting autonomic dysregulation rather than as a direct peptide therapeutic

AARS1-mediated lactylation of H3K18 and STAT1 substantially triggers renal tubular cell ferroptosis by transcriptionally activating the lipid-elongating enzyme ELOVL5 (56)

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In addition, the drugs have been shown to also improve heart health