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Recent studies indicate an alternate role of GNE in cell apoptosis and adhesion, besides SA biosynthesis
Critically, therapeutic targeting of the gut-muscle axis reduces morbidity and mortality associated with muscle dysfunction in the elderly 14 , positioning it as a key research focus for deciphering the pathophysiology of obesity-induced muscle atrophy
IGF-I signaling is required for the skeletal cell communications through RANKL/RANK, M-CSF/c-fms and ephrin B2/EphB4 signaling
Acetyl-l-carnitine (ALC) is a molecule derived from the acetylation of carnitine in the mitochondria that has an essential role in energy production
Long-chain fatty acids must be conjugated to carnitine by carnitine palmitoyltransferase I (CPT-I) to form acylcarnitine, transported across the inner mitochondrial membrane by carnitine-acylcarnitine translocase (CACT), and released by CPT-II for beta-oxidation
