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First thing in the morning on an empty stomach With no more than 4 ounces of plain water With no food, drink, or other medications for at least 30 minutes afterward Swallowed whole, without crushing or splitting The reason for these rules is that oral absorption of the medication is tricky thats why it took so long for a pill to be available, says Dan Azagury, MD, a weight loss physician and bariatric surgeon at Stanford Medicine in Palo Alto, California

Improved metabolic and immune regulation may play a role

Any rubber fragments in the solution mean the vial should be discarded

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Dimples or depressions at previous injection sites indicate lipoatrophy

Strength decreases