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Patients should be aware of the associated potential risks due to the lack of data available about its use
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Because data shows that women experience nausea and vomiting at up to 2.5 times the rate of men while on GLP-1 agonists (possibly due to higher GLP-1 receptor expression in female brain regions associated with nausea), microdosing GLP-1 medications could potentially help lower the likelihood of these effects
observed abundant autophagic vesicles and enhanced autophagic flux in SCs from the HG group (90), autophagy hyperactivity was also observed in the streptozotocin (STZ)-induced rat model of DPN in Wang et al., these effects were also found to potentially increase apoptosis in SCs and demyelination of sciatic nerves in rats with DPN (91)
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