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95 In one randomized controlled trial involving 144 healthy participants with high non-restorative sleep scores, 120 mg of a standardized extract of ashwagandha root and leaf, called Shoden, daily for six weeks improved time to sleep onset, wakefulness after sleep onset, total sleep time, and sleep efficiency as measured by actigraphy

Trimethylamine n-oxide exacerbates cardiac fibrosis via activating the NLRP3 inflammasome

Because this effect is entirely glucose-dependent, insulin secretion decreases as plasma glucose approaches normal levels, providing a significant safety advantage over traditional secretagogues

Furthermore, L-carnitine positively influences key pathways implicated in pathological skeletal muscle wasting