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Beyond their intended effect for T2DM, GLP-1 RAs can also improve overall metabolic and neurological health, decreasing risk for cardiovascular events, reducing cholesterol, and diminishing the risk of developing Alzheimers and Parkinsons Disease by treating insulin resistance (1, 3, 4)
In clinical trials, 6-16% of participants discontinued retatrutide due to gastrointestinal adverse events (Jastreboff et al., NEJM, 2023)
69 Elevations of a kidney injury marker should not come as a surprise, however, as acute kidney injury evaluation in the form of serum creatinine is included in scoring systems such as the APACHE II and KCH criteria
For research applications where the GLOW three-pathway framework already covers the research question, GLOW remains the more cost-efficient option
Watch out for sudden, severe mid-epigastric pain that radiates to the back, pain thats worse after eating or lying down, nausea or vomiting that doesnt subside, and a tender or distended abdomen
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