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In contrast, a long-term study from the Diabetes Prevention Program Outcomes Study found that metformin led to an average weight loss of about 2-5% of body weight over several years
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To assess the effect size of tirzepatide in resolving MetS relative to each comparator separately, we conducted 3 distinct IPD meta-analyses, each with different weights: 1 for RCTs with placebo (SURPASS-1 and SURPASS-5), 1 for RCTs with insulin (SURPASS-3, SURPASS-4, and SURPASS-AP-Combo), and 1 for RCTs with GLP-1 RA (SURPASS-2 and SURPASS J-mono) as the comparator
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