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& Neuhuber, W
Cell Cycle Pathway The abrogation of cell cycle checkpoint and apoptosis regulators is widely present in melanoma ( CDKN2A loss and CDK4/6 or CCND1 amplification
Preclinical and clinical safety data includes [5] : No evidence of mutagenic activity, chromosomal aberrations, or micronucleus formation in genotoxicity studies 6-month chronic oral administration studies in rats showed no toxicological concerns 9-month studies in cynomolgus monkeys revealed general safety Six human clinical trials spanning 0.25 mg to 30 mg doses for up to 6 months No serious adverse events or withdrawals related to AOD9604 intake No anti-AOD9604 antibodies detected, indicating low immunogenic potential No changes in vital signs, physical examinations, electrocardiograms, or safety-related laboratory parameters Research Applications A Quick Review AOD9604 is a peptide compound that has shown potential in research related to lipid metabolism, energy balance, and tissue regeneration
Griffiths C E, Bleiker T O, Creamer D, Ingram J R, Simpson R C
Kidney effects of Glucagon-Like Peptide 1 (GLP1): from molecular foundations to a pharmacophysiological perspective
10.1016/j.tem.2012.06.002 122 SwerN
