Additionally, the limited capacity of current animal models to fully recapitulate the multidimensional spectrum of schizophrenia, encompassing positive, negative, and cognitive symptoms, likely contributes to the poor translational success from preclinical to clinical
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Caution should be exercised in treating HIV-positive patients with lipodystrophy with tesamorelin if they develop glucose intolerance or diabetes, and careful consideration should be given to discontinuing tesamorelin treatment in patients who do not show a clear efficacy response as judged by the degree of reduction in visceral adipose tissue by waist circumference or CT scan measurements
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