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However, the TRIUMPH-1 Phase 3 trial results indicated significant weight loss, with participants losing up to 28.3% of their body weight at 80 weeks

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This is below the threshold used in clinical studies

GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss

However, their use is not without adverse effects, particularly gastrointestinal disturbances, which can impact treatment adherence and patient satisfaction [6]

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