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The triptan drugs (e.g., sumatriptan, rizatriptan, eletriptan, and almotriptan) act on several specific mechanisms of a migraine headache, such as promoting vasoconstriction and blocking pain pathways in the brainstem

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administered via single-dose autoinjector to abdomen or thigh Intranasal administration Studied extensively in Phase 2 trials but discontinued due to blood pressure elevations