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When ER zinc balance is disrupted, ER stress pathways become activated, triggering the unfolded protein response (UPR) 121,122
The relationship is complex, often involving the rapid improvement in blood sugar control that these medications provide
Huang T, Wang J, et al
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In addition, these metabolic effects do not appear to be related to their diuretic action or intended pharmacological targets, raising concerns about the long-term metabolic impact of specific diuretics, particularly in vulnerable populations, including those with metabolic syndrome
Published human trials mainly studied oral and intravenous forms, so subcutaneous amounts come from community practice rather than an approved clinical protocol
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