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Challenges: Despite their clinical benefits, several factors constrain the broader adoption of GLP-1 receptor agonists

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In diabetes, the automatic adjustments that keep a person upright stop working as smoothly

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GLP-1s are highly effective at controlling blood sugar and slowing down gastric processes, but they are also highly effective (so to speak) at bringing on side effects like constipation, nausea, and abdominal pain that, if untreated, will impact adherence and, in turn, short and long term results

Discontinuation was more common among Black or Hispanic patients, males, Medicare or Medicaid enrollees, those living in areas with high social needs, and patients with obesity, heart failure, or other cardiovascular conditions