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MOF-based nanoplatforms can also modulate anti-tumor immunity by influencing MDSCs in addition to nanocapsules, such as the (M+H)@ZIF/HA nanoparticles formed by the zeolite imidazolate framework-8 (ZIF-8) of the hyaluronic acid-modified mitoxantrone (MIT) and the DNA demethylating agent hydralazine (HYD) with pH response can convert cold tumors into antigen repertoire, stimulate robust immune responses and can effectively block MDSC-mediated T cell paralysis, triggering a strong cytotoxic T cell response to eliminate tumors (122)

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coli BL21 cells were transformed with the plasmid containing Nb35 target gene and were grown in TB medium with 100 g/mL ampicillin, 1 M MgCl 2 , 2% (w/v) glucose at 37 C, 180 rpm for 3 h

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