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Rather than targeting appetite or hormones, MOTS-c primarily affects cellular metabolism
The His-Phe-Arg-Trp tetrapeptide core (positions 69) is preserved intact and has been identified as the pharmacophore responsible for melanocortin receptor activation
Korczowska-ackaISowikowskiBPiekutTHuraMBanaszekNSzymanowiczOet al
Soluble Mediators in Liver Fibrosis The development of liver fibrosis occurs as a result of interaction between several different cell types including hepatocytes, HSCs, Kupffer cells, as well as infiltrating immune cells
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