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This triggers systemic inflammation, alters neurotransmitter production, and disrupts the blood-brain barrier, fueling mental health issues

In addition, both TTP and gAgAP downregulated transcription levels of angiotensin II receptor type 1 ( agtr1 ) and miR-132/-212, with TTP producing a comparable reduction in agtr1 to captopril and a significant decrease in miR-132/-212 expression

Nature 2020;578:444448

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Risks of topical tretinoin use during pregnancy & breastfeeding

In contrast, HSBP-1 suppression exacerbates erastin-induced ferroptosis (Sun et al., 2015)