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Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action

Without blood testing, you cant confirm oral supplements are effectively raising your B12 levels

Therapeutic Goods Administration

If you have had weight-reduction surgery or have pernicious anemia, celiac disease, or Crohn's disease, B12 injections may be recommended

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Retatrutide is an experimental triple-agonist weight-loss and diabetes drug developed by Eli Lilly that targets GLP-1, GIP, and glucagon receptors