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Amphetamine-induced depression may be associated with changes in the monoaminergic and glutamatergic systems, the hypothalamic-pituitary-adrenal (HPA) axis, chronic stress, increased inflammation, decreased levels of brain-derived neurotrophic factor (BDNF), and impacts on synaptic function, neuroplasticity, autophagy, and neurogenesis

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Inform your physician if you experience localized heart rate fluctuations, as triple-agonist formulations may modulate systemic cardiovascular markers

doi: 10.1016/j.cmet.2016.04.006 76 HuangKPAcostaAAGhidewonMYMcKnightADAlmeidaMSNyemaNTet al