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10.1016/j.chemosphere.2010.10.070 Chemosphere 68 ReymondP.WeberH.DamondM.FarmerE

So beyond its shelf life, theres a greater risk of contamination and bacterial or fungal growth in the liquid

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doi: 10.1212/WNL.0b013e3182315259 24

Injecting cold solution causes immediate vasoconstriction and sharp, burning pain that persists for several minutes post-injection